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BOTOX® Cosmetic

At 20 Years, Allergan Aesthetics Continues to Innovate

At 20 Years, Allergan Aesthetics Continues to Innovate


Allergan Aesthetics celebrates two decades of BOTOX® Cosmetic (onabotulinumtoxinA) and continues to drive innovation.

In honor of Out's 30th anniversary, the publication is celebrating another brand's major milestone. Since the FDA approved the use of BOTOX® Cosmetic to temporarily improve the appearance of moderate to severe frown lines in adults in 2002, Allergan Aesthetics has made major strides in the field of medical aesthetics over the past 20 years. Although Allergan Aesthetics has evolved significantly over the past two decades, they still have a spring in their step by continuing to evolve.

With the brand celebrating 20 years since its first FDA approval, it's especially important to highlight the more than 20 years of research behind BOTOX® Cosmetic. Since the first FDA approval, BOTOX® Cosmetic has continued to drive the immense growth that the market has experienced by pushing for more research, more data, and a better understanding of patient needs, ultimately leading BOTOX® Cosmetic to expand its indications and be the only neurotoxin FDA approved for three areas: moderate to severe frown lines, crow's feet, and forehead lines in adult patients. Since then, BOTOX® Cosmetic has continued to be manufactured to the strict quality standards of 98 different countries and has become the #1 selling treatment of its kind. After 100 million vials sold and over 4000 peer-reviewed articles, you'd think Allergan Aesthetics has reached the top, but they're just getting started.

While celebrating the company's milestone, Carrie Strom, Senior Vice President, AbbVie, and President, Global Allergan Aesthetics, makes it clear that Allergan Aesthetics is committed to innovation and ongoing research.

In the 20th celebration press release, she said, "We remain dedicated to BOTOX® Cosmetic, the first product of its kind on the market. We are passionate about continuing to drive this market forward for our patients, and our experienced team is working closely with healthcare providers to ensure we are delivering meaningful innovations that the market needs with our commitment to ongoing research."

Allergan Aesthetics has a lot of accomplishments to celebrate during this major milestone. And just like Out, Allergan Aesthetics looks to the future to see what innovations they can make, and the medical community is excited to see where they go next.

In the same press release, Dr. Jean Carruthers said, "It has been remarkable to see how BOTOX® Cosmetic has evolved in 20 years, one scientific study at a time that showcases the significance of this treatment." She continued, "BOTOX® Cosmetic has not only changed the trajectory of my career but also the way the medical aesthetics community practices and teaches. By any account, two decades is a long time, however in medicine, it is just the beginning, and I look forward to the next big milestone for BOTOX® Cosmetic."

Talk to your doctor about BOTOX® Cosmetic and whether it's right for you. There are risks with this product. The effects of BOTOX® Cosmetic may spread hours to weeks after injection causing serious symptoms. Please see additional Important Safety Information below.


  1. Data on File. AbbVie. Neurotoxin Monthly Tracker Report, Sept. 2022.
  1. With 100M vials of both BOTOX® and BOTOX® Cosmetic sold.


BOTOX® Cosmetic may cause serious side effects that can be life threatening. Get medical help right away if you have any of these problems any time (hours to weeks) after injection of BOTOX® Cosmetic:

  • Problems swallowing, speaking, or breathing, due to weakening of associated muscles, can be severe and result in loss of life. You are at the highest risk if these problems are pre-existing before injection. Swallowing problems may last for several months.
  • Spread of toxin effects. The effect of botulinum toxin may affect areas away from the injection site and cause serious symptoms including: loss of strength and all-over muscle weakness, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, and trouble swallowing.

BOTOX® Cosmetic dosing units are not the same as, or comparable to, any other botulinum toxin product.

There has not been a confirmed serious case of spread of toxin effect when BOTOX® Cosmetic has been used at the recommended dose to treat frown lines, crow's feet lines, and/or forehead lines.

BOTOX® Cosmetic may cause loss of strength or general muscle weakness, vision problems, or dizziness within hours to weeks of taking BOTOX® Cosmetic.If this happens, do not drive a car, operate machinery, or do other dangerous activities.

Serious and/or immediate allergic reactions have been reported. They include: itching, rash, red itchy welts, wheezing, asthma symptoms, or dizziness or feeling faint. Get medical help right away if you are wheezing or have asthma symptoms, or if you become dizzy or faint.

Do not receive BOTOX® Cosmetic if you: are allergic to any of the ingredients in BOTOX® Cosmetic (see Medication Guide for ingredients); had an allergic reaction to any other botulinum toxin product such as Myobloc® (rimabotulinumtoxinB), Dysport® (abobotulinumtoxinA), or Xeomin® (incobotulinumtoxinA); have a skin infection at the planned injection site.

Tell your doctor about all your muscle or nerve conditions, such as ALS or Lou Gehrig's disease, myasthenia gravis, or Lambert-Eaton syndrome, as you may be at increased risk of serious side effects including difficulty swallowing and difficulty breathing from typical doses of BOTOX® Cosmetic.

Tell your doctor about all your medical conditions, including: plans to have surgery; had surgery on your face; have trouble raising your eyebrows; drooping eyelids; any other abnormal facial change; are pregnant or plan to become pregnant (it is not known if BOTOX® Cosmetic can harm your unborn baby); are breast-feeding or plan to (it is not known if BOTOX® Cosmetic passes into breast milk).

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using BOTOX® Cosmetic with certain other medicines may cause serious side effects. Do not start any new medicines until you have told your doctor that you have received BOTOX® Cosmetic in the past.

Tell your doctor if you have received any other botulinum toxin product in the last 4 months; have received injections of botulinum toxin such as Myobloc® , Dysport® , or Xeomin® in the past (tell your doctor exactly which product you received); have recently received an antibiotic by injection; take muscle relaxants; take an allergy or cold medicine; take a sleep medicine; take aspirin-like products or blood thinners.

Other side effects of BOTOX® Cosmetic include: dry mouth; discomfort or pain at the injection site; tiredness; headache; neck pain; and eye problems: double vision, blurred vision, decreased eyesight, drooping eyelids and eyebrows, swelling of your eyelids and dry eyes.

BOTOX® Cosmetic is a prescription medicine that is injected into muscles and used to temporarily improve the look of moderate to severe forehead lines, crow's feet lines, and frown lines between the eyebrows in adults.

For more information refer to the Medication Guide or talk with your doctor.

To report a side effect, please call Allergan at 1-800-678-1605.

Please see BOTOX® Cosmetic full Product Information, including Boxed Warning and Medication Guide.

BCT159069 11/22

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