"Let's fight hate & ignorance with love for trans teens, who are already facing steep odds and who need our support to grow and THRIVE," Dunham said.
The Girls creator has also pledged to match donations to the center up to $50,000.
The issue is a personal one for Dunham, whose younger sibling is gender non-confirming. Grace Dunham came out in 2016 saying, "I'm not a woman, but I'm not a man," as they stripped down for StyleLikeU's online video series, "The What's Underneath Project."
The Ruth Ellis Center is one of only four organizations in the U.S. that provides shelter and services to at-risk LGBT youth. Click here to donate.
Years before Stonewall, a cafeteria riot became a breakthrough for trans rights
All about the Compton's Cafeteria riot, when drag queens and trans women rose up against police at a diner in San Francisco.